Treatment and Prevention

Amoxiclav syrup: instructions for use

Amoxiclav syrup is a non-existent form of the drug. Apply suspension to treatment. The drug has a broad spectrum of antimicrobial action. It is active against many pathogenic infections.

Existing forms of production and composition

There are 2 main forms of release: tablets, film-coated (125, 250 and 500 mg), and cream or white powder for suspension.

Amoxiclav syrup is a non-existent form of the drug. Apply suspension to treatment.

The main active ingredients: amoxicillin 250 mg (in the form of the trihydrate) and clavulanic acid, which in the preparation is contained in the form of potassium salt.

Additional components are: citric acid, sodium citrate, microcrystalline cellulose, xanthan gum, silicon dioxide, flavors, sodium benzoate, saccharin.

The drug is packaged in vials. In a cardboard pack there is 1 bottle and a piston pipette to it.

International non-proprietary name

INN: Amoxicillin + clavulanic acid

ATX

J01CR02

pharmachologic effect

Refers to systemic antibacterial agents. Amoxicillin is a semi-synthetic antibiotic. It is active against many gram-positive and gram-negative microorganisms. It breaks down under the influence of some beta-lactamase. Therefore, the effect of the substance does not apply to microorganisms that produce this enzyme.

Amoxicillin is a semi-synthetic antibiotic.

Clavulanic acid is almost the same in structure as many penicillins, but it can inhibit the action of lactamase. Therefore, with the combination of these 2 substances, the antibiotic is not destroyed, and its spectrum of action expands.

Pharmacokinetics

The active components are well absorbed from the organs of the gastrointestinal tract. The maximum of them in the blood is reached in an hour after using the medicine. Absorption is improved by taking the medication before or during meals. Bioavailability and ability to bind to protein structures is low. Excreted by renal filtration in the form of major metabolites.

Indications for use Amoxiclav

Appointed in the following clinical cases:

  • bacterial sinusitis;
  • acute otitis media;
  • acute and chronic bronchitis;
  • pneumonia;
  • cystitis;
  • pyelonephritis;
  • skin and soft tissue infections;
  • infections of bones and joints.
Amoxiclav is prescribed for pyelonephritis.
Amoxiclav is prescribed for bacterial sinusitis.
Amoxiclav is prescribed for pneumonia.
Amoxiclav is prescribed for acute otitis media.
Amoxiclav is prescribed for cystitis.

Contraindications

Prohibited by:

  • hypersensitivity to constituents;
  • the presence of hypersensitivity reactions to cephalosporins;
  • jaundice or liver impairment associated with amoxicillin.

How to take Amoxiclav?

In selecting the dosage, the type of pathogenic microorganisms that caused the disease and their sensitivity to this antibiotic are taken into account. What matters is the age, weight and condition of the kidneys of the patient.

Suspension is intended for intravenous administration. Before using the bottle with the powder shaken, so that it is separated from the walls. To prepare 100 ml of solution, it is necessary to add boiled water to the vial:

  1. First up to 2/3 of the bottle.
  2. Then - to the circular mark, which is located in the recess of the bottle.

After each addition of water, the bottle should be shaken so that all the particles of the solution are mixed and dissolved. Shake the bottle before use.

To measure the required amount of suspension, a piston pipette with graduations of 0.1 ml is packaged. Its volume is 5 ml. The amount of suspension is measured on the basis of weight, not age. The same dose of the drug is administered every 8 hours.

Suspension is intended for intravenous administration.

For adults and children whose weight is more than 40 kg, the maximum amount per day is 625 mg divided into 3 doses.

Before or after meals?

To reduce the negative effects of the antibiotic on the digestive system, it is recommended to take the medicine before meals.

Taking the drug in diabetes

Allowed. Active substances do not cause an increase or decrease in sugar, so do not worry about the development of hyperglycemia. The only thing is that the course of treatment for people with diabetes will be longer.

Side Effects of Amoxiclav

Possible side effects in violation of the dose or failure to comply with the reception.

Gastrointestinal tract

Often: nausea, sometimes even vomiting. There are symptoms of intoxication, dyspepsia, pain in the stomach.

Hematopoiesis

Leukopenia and thrombocytopenia. Extremely rare: hemolytic anemia and an increase in prothrombin time.

Taking Amoxiclav can cause nausea and vomiting.

central nervous system

Headache, dizziness, insomnia, agitation, aseptic meningitis and convulsions.

On the part of the urinary system

Extremely rare: crystalluria and nephrite.

Since the cardiovascular system

The appearance of tachycardia and arrhythmia. This is especially true for elderly patients.

Allergies

Skin rashes, urticaria, angioedema, in severe cases, bronchospasm and anaphylactic shock.

special instructions

Before starting treatment, you must make sure that the patient is not allergic to antibiotics - penicillins and cephalosporins. Because some microorganisms have a high resistance to this drug, it should not be used to treat acute pneumonia.

In patients with impaired renal function and liver, convulsive syndrome may develop during treatment with large doses of the drug. It is necessary to constantly monitor changes in the work of these bodies.

In patients with impaired renal function, convulsive syndrome may develop during treatment with large doses of the drug.

Not prescribed for infectious mononucleosis. With its long-term use it is possible the development of enterocolitis, the appearance of superinfection, fungal lesions and the development of resistance of microorganisms to active substances.

How to give children?

Newborns and children up to 2 months taking medication is not recommended. For children under 2 years of age, the daily dose is 50 ml per kg of body weight.

Children from 2 to 12 years are assigned to 75 ml, divided into 3 doses. For children over 12 years old and weighing more than 40 kg, the daily dose is prescribed as for adults.

During pregnancy and lactation

Teratogenic effects on the fetus have not been proven, but necrotizing enterocolitis may develop in infants if a woman has been treated with this antibiotic in the gestational period. In this regard, the medication is not recommended.

Because active ingredients can pass into the mother's milk, causing digestive disorders and candidiasis of the oral mucosa in the newborn, the antibiotic is not accepted, or the child is transferred to artificial mixtures.

Overdose

Manifested by a disorder of the digestive tract and impaired water and electrolyte balance. Treatment will be symptomatic and directed mainly to the restoration of water and electrolyte balance. The appearance of convulsive syndrome in patients with impaired renal function and people exceeding the dose of the medicine is possible.

The combination of Amoxiclav with Allopurinol increases the risk of unwanted allergic reactions.

Interaction with other drugs

With simultaneous use with Probenecid, amoxicillin secretion in the kidneys is reduced. Its plasma level rises. Therefore, this combination is not recommended.

Combination with allopurinol increases the risk of unwanted allergic reactions. Reception with other antibiotics greatly affects the intestinal microflora. The effectiveness of the application of OK is reduced.

Can not be combined with macrolides, sulfonamides and tetracyclines. When used together, it increases the toxic effects of methotrexate.

Analogs

Substitutes include:

  • Abiklav;
  • A-Clave-Farmex;
  • Amoxiclav Quiktab;
  • Amoxicomb;
  • Amoxyl-K;
  • Amoxicillin;
  • Augmentin;
  • Claudia;
  • Medoclav;
  • Novaklav;
  • Panklav;
  • Rapiklav;
  • Flemoklav Solyutab.
The substitute drugs Amoxiclav is Panklav.
By drugs Amoxiclav is Augmentin.
For substitute drugs Amoksiklava refers Flemoklav Solyutab.
Rapiklava is a substitute drug for Amoxiclav.
Medoclav is a substitute drug of Amoxiclav.

Pharmacy vacation terms

On prescription.

Can I buy without a prescription?

You can not buy medicine without a prescription.

Price

From 210 to 300 rubles.

Drug storage conditions

At room temperature.

Shelf life

2 years.

Manufacturer

Lek Pharmaceutical Company dd, Slovenia.

Reviews of doctors and patients

Doctors

Yury, 41 years old., Doctor of family medicine, Minsk

Often I prescribe this suspension, especially for small children who have a hard time swallowing pills. Convenient form and quick action. Infections kill almost everything. The only thing you need to initially check the child for hypersensitivity to the active substances, to prevent the development of an allergic reaction.

Svetlana, 48 years old, therapist, Saratov

I appoint both suspension, and tablets. Suspension is more suitable for children. It can be clearly measured to prevent overdose. The effect of the drug is satisfied. This treatment helps most patients.

AMOKSIKLAV
Amoxiclav

Of patients

Julia, 32 years old, Kiev

Recently, my daughter found otitis. The doctor immediately prescribed Amoxiclav suspension. The treatment went well, improvement quickly came, literally on the second day. Symptoms of otitis disappeared after 5 days of taking the medicine.

Oleg, 24 years old, Odessa

I had a sharp otitis. The doctor advised this antibiotic to eliminate the symptoms of the infection. He helped well, but on day 3 severe headache and nausea began. Then came a strange rash on the skin. Had to be replaced with another medicine.

Marina, 30 years old, Kharkov

An antibiotic helped. The kidneys started to hurt, and after the examination the doctor diagnosed pyelonephritis. The doctor said that I caught an infection. Prescribed treatment Amoxiclav. The acute symptoms went away after a couple of days. But the treatment was completed. Only at the beginning of the medication was there a slight indisposition, but then everything went away.

Watch the video: Clavulanic Acid Clavulanate and Penicillin Protection (September 2019).