Metformin analogues can be found in every pharmacy. There are a sufficient number of such medicines today.
They may differ in price, manufacturer or dosage. Combines all these drugs the main active ingredient - Metformin hydrochloride. It is thanks to him that the hypoglycemic effect of taking such medications is achieved.
Drugs containing metformin are included in the group of third-generation biguanide drugs. Their main advantage is that the hypoglycemic effect begins to manifest itself gradually without reaching too low levels.
What is the active substance Metformin?
The active substance metformin (international non-proprietary name - iHH) is the main active component of a variety of tablet means, which is often prescribed to patients with diabetes mellitus. This is a hypoglycemic medication from the third generation biguanide group.
Hypoglycemic medication inhibits gluconeogenesis, the transport of free electrons in respiration reactions in the mitochondria.
Metformin stimulates the reactions of glycolysis processes, the cells begin to digest glucose more quickly and to a greater extent. Medication helps to reduce the absorption of sugars from the lumen of the gastrointestinal tract into the blood plasma. The drug does not cause a sharp decrease in the level of carbohydrates in the blood plasma, since it does not have an activating effect on the processes of insulin production.
The mechanism of action of the active component on the human body is the manifestation of the following effects:
- Reduces the level of glycogen reduction from an organ such as the liver. As a result, there is a basal increase in blood glucose levels.
- Slows down the process of glucose synthesis from proteins and lipids.
- It has a positive effect on the stimulation of glucose deposition in the liver.
- It helps to neutralize the manifestation of insulin resistance and increases the sensitivity of cells and tissues to this hormone, which is produced by the pancreas.
- It has a beneficial effect on the decrease in the absorbability of glucose by the intestines.
- Promotes the conversion of glucose into lactate in the organs of the digestive tract.
- Increases blood lipids. In addition, a decrease in the amount of bad cholesterol in the body is simultaneously observed.
- Causes muscles to absorb more glucose.
Preparations with metformin have one indisputable advantage compared with other medications - it does not lead to the development of hypoglycemia, that is, the level of carbohydrates in the blood does not fall below the normative levels.
Instructions for use of any drug based on metformin suggests that the indication for admission may not only be developing diabetes mellitus. Tablets can also be taken in such cases:
- if there is a violation of the glucose tolerance or problems with glycemia develop upon awakening;
- with the development of insulin resistance and a significant increase in weight (especially in the abdomen) ꓼ
- gynecology uses drugs metformin for the treatment of ovarian clearotikosisоза
- during the manifestation of metabolic syndromeꓼ
- as a prophylactic to prevent aging.
The active ingredient has a positive effect on the brain and reduces the risk of developing Alzheimer's disease.
What are the trade names of the drug?
Drugs with metformin in pharmacies provided in sufficiently large quantities. Modern pharmacology and manufacturers produce multiple analogues in different dosage forms. These can be tablets or capsules.
The group of such a medicine includes various types of drugs.
The original drug Metformin Teva. In such tablets can be from 0.5 to 1.0 grams of active substance. Depending on the progression of the disease, the attending physician prescribes medication with the required amount of metformin hydrochloride. An Israeli manufacturing company is responsible for the production and effectiveness of the tablets. Metformin Teva is a hypoglycemic medication. It is prescribed for the development of type 2 diabetes. In addition, in addition to the usual dosages, tablets can be presented in a form such as long-acting metformin. The price of the drug will depend on the amount of active ingredient in the pill. The average cost, depending on the dose of the active component in the composition of the medical device, varies from 77 to 280 rubles.
Myotformin Canon - a representative of a foreign drug in Russia. Its manufacturer is the Russian pharmacological enterprise Kanonfarma Production. Capsule tablets of this drug may contain 500, 850 or 1000 mg of the active ingredient. The drug is effective as a sugar reducing agent, and also contributes to the normalization of excess weight, especially when diet is followed. Metformin Canon has proven itself in the pharmacological market. Its cost is relatively low and varies from 89 to 130 rubles, depending on the required dosage.
Metformin Zentiva is a more expensive representative of such a group of sugar-reducing agents. The price of the drug can be from 118 to 200 rubles. The manufacturer is the Slovak company, which offers its customers a medicinal product in the following dosages - 0.5, 0.85 or 1 gram of the active substance. As a rule, Metformin Zentiva is prescribed to normalize the level of carbohydrates in the blood, as well as if there is insulin resistance in patients older than ten years of age.
Metformin Richter is included in analogues of metformin, produced by one of two manufacturing companies. The geographical location of the pharmacological company is the Russian Federation and Hungary. The composition of the drug contains from 500 to 1000 mg of the active ingredient. The mechanism of action of metformin is to eliminate hyperglycemia and normalize excess weight.
Often such a drug is prescribed as a replacement for the previous medication. The cost of the drug ranges from 180 to 235 rubles.
How to take medicine?
Tablets based on metformin hydrochloride are usually prescribed when the first signs of diabetes develop.
The initial dosage of the drug should not be higher than 0.5 grams of the active ingredient. Your doctor may recommend taking the tablets with or after a meal, depending on the individual needs of the patient. The number of doses of the drug should not exceed two or three times a day. Only one or two weeks after the start of the therapeutic course, the upward revision of the prescribed doses is allowed. The maximum possible daily dosage should not exceed two grams of the active ingredient. It should be borne in mind that if you apply the drug before the start of a meal, the effect of the active ingredient may dramatically decrease. In some cases, Metformin is combined with insulin injections. Thus, an increase in the effect of injections is achieved.
In Metformin pharmacokinetics suggests that the drug after oral administration, reaches its maximum plasma concentration in about two and a half hours.
The absorption of the active ingredient is stopped after six hours after the use of tablets.
The most popular analogues of Metformin are Siofor and Glucophage.
What can replace Metformin tablets? What pharmaceutical preparations enjoy particular popularity among consumers?
One of the most popular medicines of the biguanide group is Ciofor, which is produced in tablet form. Metroformin hydrochloride acts as the main active component of the medicinal substance; silicon dioxide, povidone, magnesium stearate, macrogol are used as auxiliary components.
Siophore 1000 in diabetes is used to lower blood sugar levels. At the same time, a decrease in indicators occurs not only after the main meal, but also allows to reduce the basic level. The main active component in Siofor allows you to regulate insulin production by the pancreas, which has a positive effect on the body and does not provoke the development of hypoglycemia.
The main indications for which Siofor is prescribed are diabetes of the second type, which is not accompanied by insulin therapy. The action of Siofor is also well manifested with the ineffectiveness of diet therapy.
The active ingredient, which is part of, manifests itself in slowing the absorption of glucose in the small intestine, neutralizes its production by the liver cells.
Glucophage is similar in composition and is an agent based on metformin hydrochloride. To date, you can purchase tablets of conventional or prolonged action. Medical studies have shown that taking Glucophage tablets is two times less likely to cause adverse reactions from the organs of the gastrointestinal tract.
At the same time, the cost of Glucophage Long is much higher than that of other tablet preparations.
What else can replace a medical drug?
How to replace Metformin? This question may arise in every diabetic. Today, there are more than a hundred drugs that are synonymous or generic analogs.
Their composition may include metformin hydrochloride, as the main substance or to be one of them (in combination drugs). The originals are presented in the form of cheaper or expensive tablet means. The price difference may depend on the manufacturer or dosage of the medicine.
The most popular names for similar drugs are:
What is best suited to the patient, can only decide the specialist who is leading his illness.
For example, Gliformin is also a representative of the biguanide class, which includes metformin hydrochloride. Similar properties of its effects on the body are explained by the fact that its composition contains the same active substance. Gliformin contributes to additional stimulation of insulin secretion by beta cells, and also has a positive effect on peripheral utilization of increased glucose by the muscles.
If you simultaneously take Gliformin with other hypoglycemic drugs, it increases its effect on lowering blood sugar levels.
Is there a difference in the means with a single active ingredient?
Sometimes you can find reviews of patients that the use of Metformin substitutes does not bring the same positive effect. Some begin to show various adverse reactions. It should be noted that the decision on the need to replace the drug should come exclusively from the attending physician, depending on the degree of development of the pathology, as well as the individual characteristics of the patient. That is why it is not worthwhile to independently search for drugs that are included in the analogues of the medicine prescribed by the doctor.
In addition, various medical devices may have a single active ingredient, but differ in the quantitative composition of the aids. It is these additional components that can cause possible harm to the body and cause the manifestation of side effects.
That is why, the opinion of specialists is that the drug-analogues can replace the main drug only if such decision was made by the attending physician. As a rule, when switching to taking other medications, the lack of a positive result occurs if the correct regimen or dose of the drug is not followed and if there is a violation in the diet.
What medications can be used for diabetics will tell an expert in the video in this article.