Treatment and Prevention

How to use the drug Nativ?

Native is used to treat diabetes insipidus, urinary problems and bed wetting in adults and children. Safe and optimal composition, as well as minimal contraindications make taking these pills convenient.

ATH

ATC classification: Desmopressin - H01BA02. INN: Desmopressin.

Native is used to treat diabetes insipidus.

Forms of release and composition

Form release - tablets with a content of 100 μg or 200 μg of desmopressin acetate (active substance). Additional ingredients in the composition:

  • XL Crospovidone;
  • ludipress;
  • lactose monohydrate;
  • Povidone;
  • crospovidone.

Tablets are placed in plastic bottles with a desiccant and lids of 30 pcs.

pharmachologic effect

The active substance of the drug - an analogue of the natural hormone vasopressin-arginine, has antidiuretic effect. It increases the degree of permeability of epithelial cells localized in the distal compartments of the water-nephron tubules, increasing the reabsorption of fluid.

Pharmacodynamics of the drug is aimed at smooth muscles of internal organs and blood vessels.

Pharmacodynamics of the drug is aimed at smooth muscles of internal organs and blood vessels and in rare cases causes spastic negative manifestations. Compared with vasopressin, the active ingredient of the drug under consideration has a longer effect and does not provoke blood pressure surges.

The ultimate anti-dyuric effect of the drug is observed 4-7 hours after its oral administration.

Pharmacokinetics

The indicator Cmax (maximum concentration of a substance in the blood plasma) is reached in 50-60 minutes. Food can reduce the absorption level of medication from the gastrointestinal tract by 40%. The substance is not able to overcome the blood-brain barrier.

For the removal of the drug are responsible kidneys. The duration of semi-splitting is from 1.5 to 3 hours.

For the removal of the drug are responsible kidneys.

Indications for use

  • therapy of the central form of diabetes insipidus;
  • elimination of manifestations of nighttime polyuria (in a complex);
  • primary form of bedwetting in children (from 5 years).

Contraindications

  • hypersensitivity to the components;
  • polydipsia (psychogenic / primary);
  • heart failure and other pathologies involving the use of diuretic drugs;
  • kidney failure (with creatinine clearance less than 50 ml / minute);
  • hyponatremia (with a plasma concentration of sodium ions less than 135 mmol / l);
  • lack of lactase, galactose-glucose malabsorption syndrome;
  • disruption of the antidiuretic hormone synthed;
  • age under 4 years.
Native is contraindicated for heart failure.
Native is contraindicated in case of hypersensitivity to the components.
Native is contraindicated in case of a lack of lactase.

Tablets with caution are prescribed for fibrous lesions of the bladder, the risk of increased intracranial pressure, elderly patients and during pregnancy.

Dosage and administration

The drug should be taken orally. His doses are selected by the doctor depending on the clinical picture of the patient. According to the instructions on the use of tablets, it is better to drink after a meal, since nutritional products may impair the absorption properties of the drug.

For the treatment of the primary form of nocturnal enuresis, the initial dosage is about 0.2 mg at bedtime. If there is no positive trend, then the amount increases to 0.4 mg per day. The average duration of therapy is 2.5-3 months.

The drug should be taken orally.

Night polyuria begin to be treated with doses of 0.1 mg at bedtime. If the pharmacotherapeutic effect is absent within 1 week, the dosage is increased to 0.2-0.4 mg. Periodicity should be no more than 1 time per week.

Use at the central not diabetes mellitus

The use of the drug in this disease helps to reduce the amount of urine released and increase its osmolarity. In addition, the drug lowers the osmolarity of the blood plasma. Such a pharmacotherapeutic effect can reduce the frequency of urination and eliminate the signs of nocturnal polyuria.

For the treatment of this pathology, the average initial dose for patients older than 4 years is 0.1 mg 1-2 times a day. Further dosage adjustment is carried out depending on the effectiveness of therapy. On average, the daily amount of the drug varies in the range of 0.2-1.2 mg / day.

The use of the drug for diabetes insipidus reduces the amount of urine excreted and increases its osmolarity.

Side effects

Most often, negative reactions when taking this drug develop in the absence of restrictions on fluid intake - hyponatremia and fluid retention appear.

When combined with imipramine and / or oxybutynin there is a risk of hyponatremia convulsions and severe vomiting.

Gastrointestinal tract

  • feeling nauseous;
  • vomiting.

central nervous system

  • convulsive phenomena;
  • confusion;
  • aching headache;
  • dizziness.
Side effects from the central nervous system: dizziness.
Side effects from the central nervous system: aching headache.
Side effects from the central nervous system: convulsive phenomena.

On the part of the urinary system

  • urinary retention (acute).

The cardiovascular system

  • arrhythmia;
  • changes in blood pressure (up or down).

special instructions

The drug is undesirable to use with additional factors of electrolyte imbalance and fluid retention.

If gastroenteritis or febrile illness occurs, the medication should be stopped and consulted with a doctor.

If gastroenteritis or febrile illness occurs, the medication should be stopped and consulted with a doctor.

Influence on ability to operate mechanisms

During clinical trials there were no significant changes in the speed of psychomotor reactions and concentration. However, given the risk of adverse reactions, at the time of treatment it is better to abandon the control of the car and work, which requires attentiveness and concentration.

Use in old age

For the treatment of persons over 65 years old, the drug is used with extreme caution and after thorough diagnosis. This is due to an increased risk of negative reactions. In addition, these patients need to monitor plasma concentrations of sodium and the general state of the body at each increase in dosage.

For the treatment of persons over 65 years old, the drug is used with extreme caution and after thorough diagnosis.

Assigning a Nativ to Children

Prohibited for use in patients up to 4 years.

Use during pregnancy and lactation

During laboratory studies, no negative reactions were recorded when the drug was taken by pregnant women. But medication is prescribed only if the perceived risks are lower than the expected benefits.

Overdose

Clinical manifestations: fluid retention, convulsive seizures, edema, hyponatremia. Symptomatic therapy. When hyponatremia drug should be abolished. If necessary, the patient is prescribed an infusion of sodium chloride solution. If there is an acute fluid retention (coma or convulsive phenomena), then furosemide is additionally used.

When combined with other means increases the effectiveness of hypertensive drugs.

Interaction with other drugs

When combined with other means increases the effectiveness of hypertensive drugs. In combination with lithium preparations, buformin, tetracycline and norepinephrine, the antidiuretic effect of the tablets in question is reduced.

The absorption of the drug is reduced when it is combined with dimethicone and desmopressinom. With simultaneous use of the drug with loperamide, there is a risk of a significant increase in the plasma concentration of desmopressin, which can lead to the development of hyponatremia and acute fluid retention. Other medications that inhibit peristalsis can provoke a similar effect.

Manufacturer

Russian company "Farm Standart".

Analogs

  • Minirin;
  • Antiqua Rapid;
  • Adiuretin DM (capsules, drops, solution for inhalation);
  • Nourem;
  • Minirin Melt;
  • Emosint;
  • Presinex.

The drug is on prescription.

Pharmacy vacation terms

Medical prescription.

The price of the drug Nativ

From 1300 rub. per pack of 30 tablets of 0.1 mg.

Storage conditions of the drug Nativ

Tablets should be kept out of the reach of moisture and light. Temperature - not higher than + 26 ° C.

Shelf life

Up to 2 years.

Minirin
Diabetes insipidus

Nativ Reviews

Olga Grigorieva, 43 years old, Dmitrov

A few months ago I ran into a problem of too frequent urination. They were in no hurry to turn to doctors, believing that these were "standard" manifestations of cystitis or a cold. As a result, I had to go to the doctor who prescribed these pills. Now the problem is solved, and I keep the case in the first-aid kit in case of the recurrence of pathology.

Kira Lopatkina, 39 years old, Norilsk

When I arrived at my country house at the beginning of the summer, I began to visit the "restroom" often. At the same time a large amount of urine was excreted. First decided that in my body develops some dangerous inflammation. Went to the hospital. After the tests, I learned that I was diagnosed with polyuria. The doctor gave a prescription for the purchase of this medication. The first course has been cut during the week. The condition has stabilized, the urge to urinate became less frequent, and the discomfort disappeared.

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