Treatment and Prevention

How to use Digan 500 for diabetes

Digit 500 is one of the frequently recommended antibiotics used to treat infections that cause severe and dangerous complications.

International non-proprietary name

The trade name of this drug is Cifran® (Cifran®). The international unlicensed name is Ciprofloxacin (Ciprofloxacin). In Latin - Ciprofloxacinum.

Digran is active against most bacteriophages and strains of pathogenic microorganisms.


J01MA02 Antibacterial drugs of systemic action.

Forms of release and composition

White coated tablets, each containing 0.5 g of the active substance - ciprofloxacin.

Oblong pills are engraved with "500" on one of the surfaces. Packed in blisters of 10 pcs.

pharmachologic effect

Digran is active against the majority of bacteriophages and strains of pathogenic microorganisms resistant to aminoglycosides. Therefore, health professionals recommend this drug to combat mixed infections caused by anaerobic, aerobic bacteria and gastrointestinal infections. The bactericidal effect of ciprofloxacin is due to the ability to inhibit the synthesis of enzymes necessary for the life of the microorganism.

Health care professionals recommend Cifran to combat mixed infections.


Quickly absorbed from the upper sections of the small intestine. The maximum concentration of the drug in the body is achieved within 1-1.5 hours after administration. At the same time, eating food does not affect the rate of absorption.

Biotransforming in the liver. From the body begins to be removed after 3-5 hours mainly with urine and partially through the intestines. In people with kidney disease, the half-elimination of the drug takes longer.

What helps

It is prescribed for uncomplicated and complicated diseases provoked by infections:

  • broncho-pulmonary system;
  • ENT organs;
  • eye;
  • oral cavity;
  • kidney and urinary system;
  • abdominal cavity;
  • musculoskeletal system.

For children, this tool is prescribed for the treatment of damage associated with cystic fibrosis of the lungs.


Digran is not prescribed if the patient has:

  • sensitivity to quinolone drugs;
  • pseudomembranous colitis;
  • any form of epilepsy.

Digran is not recommended to be used during pregnancy and during the lactation period.

In addition, according to the instructions for use, this tool is not recommended for use during pregnancy and during the lactation period.

It is prescribed to children and adolescents only to combat infections caused by cystic fibrosis or the threat of anthrax infection.

Digran is not used in combination with tizanidine.


Be wary appoint age patients, as well as:

  • with cerebral atherosclerosis and increased intracranial pressure;
  • with heart disease;
  • electrolytic failures;
  • with renal and / or liver pathologies;
  • with mental illness and epilepsy.

Digran 500 is taken before meals, without chewing and drinking water.

It has limitations if a person has been diagnosed with diseases of the ligamentous apparatus, provoked by taking fluoroquinolones.

How to take Digran 500

Take before meals, without chewing and drinking water.

Adults for the treatment of diseases occurring:

  • in mild and medium forms - 0.25-0.5 g twice a day;
  • in severe or complicated form - 0.75 g twice a day.

The duration of treatment is determined by the form and severity of the infection. Therapeutic schemes are prescribed by the doctor individually.

The maximum one-time dosage of the drug is 0.75 g, daily - not more than 1.5 g.

In diseases of the liver or kidneys, the maximum daily dosage should not exceed 0.8 g (0.2-0.4 g every 12 hours).

If a patient has diabetes mellitus, antibacterial therapy regimens are prescribed by a doctor individually.

With diabetes

Ciprofloxacin presumably enhances the effect of hypoglycemic drugs. Therefore, when combined with this substance, for example, with Glibenclamide or Glimepiridom, hypoglycemic syndrome may develop.

If a patient has diabetes mellitus, antibacterial therapy regimens are prescribed by a doctor individually.

Side effects

The use of this antibiotic can cause various side effects. For example, on the part of the musculoskeletal and ligamentous apparatus, a patient may develop: arthralgia, muscle cramps, swelling of the joints, exacerbation of symptoms of myasthenia, etc.

Since the cardiovascular system

Sensation of palpitations, arrhythmia, tachycardia, changes in blood pressure.

Digital may cause side effects in the form of heart palpitations, arrhythmias, tachycardias, changes in blood pressure.

On the part of the urinary system

Abnormalities in the kidneys. Sometimes it is possible the development of renal failure, hematuria, tubulointerstitial nephritis.


In rare cases, the development of eosinophilia, iron deficiency states, neutropenia, leukocytosis, thrombocytopenia, thrombocythemia.

Gastrointestinal tract

Nausea (up to vomiting), diarrhea, dysbiosis, sometimes candidiasis.

central nervous system

Some patients have signs of asthenia, sleep disturbances, anxiety, hearing loss, taste receptor dysfunction, etc.

Some patients have sleep disturbances.


Angioedema, skin rash, itching and anaphylactic reactions (rare).

special instructions

Patients with a history of epilepsy, convulsions, vascular pathologies or organic brain lesions in the history of the disease are at risk of an inadequate response from the central nervous system. In some cases, a state of psychosis occurs, accompanied by suicidal attempts. Therefore, this drug is prescribed only for vital signs.

When using this medication, it is necessary to avoid exposure to sunlight, since it contributes to the manifestations of photosensitization.

Compatibility with alcohol

The joint use with alcohol is inadmissible.

The joint use of the drug Tsifran with alcohol is unacceptable.

Influence on ability to operate mechanisms

When taking the drug should refrain from driving and other potentially dangerous machinery.

Use during pregnancy and lactation

Use during pregnancy is contraindicated. If necessary, treatment during the lactation period, you must abandon breastfeeding.

Purpose Digital to 500 children

Children and adolescents up to 18 years old can only be prescribed in the treatment of diseases caused by cystic fibrosis or the threat of anthrax infection.

Use in old age

For aged patients with impaired immunity, previously treated with glucocorticosteroids, there is a risk of rupture of the Achilles tendon. Therefore, when symptoms of tendinitis appear, Ciran should be discontinued.

For aged patients with impaired immunity, there is a risk of rupture of the Achilles tendon.

Use in violation of kidney function

With kidney disease in order to avoid the threat of side effects, the increase in prescribed dosages is unacceptable. In addition, during the day it is necessary to drink enough liquid.


Symptoms: dizziness, headaches, feeling of weakness, nausea, vomiting. In cases of overdose, standard detoxification procedures should be carried out:

  • gastric lavage;
  • administration of emetic preparations;
  • taking calcium and magnesium-containing agents;
  • use of large volumes of fluid.
In cases of overdose, it is necessary to wash the stomach.
In cases of overdose, the appointment of emetic preparations is necessary.
In cases of overdose, the use of large volumes of fluid.

In addition, you need to monitor the performance of the urinary system, since the uncontrolled use of medication has a toxic effect on the kidneys.

Interaction with other drugs

At the same time taking heart drugs, antidepressants and neuroleptics is prescribed with caution.

In combination with Theophilin enhances its action and contributes to the delay in the body.

With simultaneous use with phenytoin, there is a change in its presence in the blood. To prevent the onset of convulsive states, it is necessary to control treatment with phenytoin throughout the entire period of joint therapy.

NSAIDs (other than acetylsalicylic acid), in combination with high doses of quinolones, can cause convulsions.

Quickly about medications. Ciprofloxacin

Cyclosporine in combination with Cifran helps to increase the content of creatinine in the body.

Probenecid delays the release of ciprofloxacin in the urine.

In combination with Methotrexate, it slows down its renal-tubular transport and increases its concentration.

Complex appointment Digit with vitamin K antagonists enhances their anticoagulant properties.

In combination with ropinirole or lidocaine increases the risk of adverse events.

In combination with warfarin increases the risk of bleeding.

Structural analogue of Tsifran on active ingredient is Tsiprolet.


Structural analogues of the active substance are:

  • Alzipro;
  • Tsiprolet;
  • Ciprolone;
  • Tsiprobay;
  • Cipropane;
  • Tsiprosan;
  • Tsiprosin;
  • Tsiprosol;
  • Ciprofloxabol;
  • Ciprofloxacin;
  • Ceteral;
  • Cifloxinal;
  • Digran OD;
  • Digran CT;
  • Ecocifol and others

The duration of treatment is determined by the form and severity of the infection.

Pharmacy vacation terms

On prescription.

Can I buy without a prescription

Most online pharmacies omit this drug without a prescription from a doctor.

The price of Digran 500

The minimum cost is from 80 rubles.

Drug storage conditions

At a temperature up to 25 ° C, in the place protected from moisture. Hide from children.

Shelf life

3 years.


Sun Pharmaceutical Ind Ltd, India.

Many doctors recommend the drug Cifran 500 to their patients as antibacterial therapy.

Reviews of doctors and patients about Cifran 500

Berezkin AV, therapeutist, Mezhdurechensk

Broad-spectrum antibiotic used in surgery, dentistry, gynecology, urology and other specialties. I myself prescribe this drug rarely, only if there is evidence or as a prophylaxis after purulent operations and injuries. I consider it effective and convenient to use.

Kornienko L.F., gynecologist, Irkutsk

The drug is suitable for outpatient treatment of inflammatory gynecological diseases. A wide spectrum of action determines the effectiveness of the therapy.

Alla, 25 years old, Ufa

I got sore throat and the doctor prescribed Tsifran tablets 500 mg 1 time per day. In the nearest pharmacy in the proper dosage of this antibiotic was not. I bought it in a dosage of 250 mg and took 2 pills at once. Sore throat passed in 3 days, but did not interrupt the course. Took 10 days. Frightened by the side effects: a sudden onset of tachycardia with dysbiosis is an unpleasant combination. Now I treat this remedy with caution and it is unlikely I will take it even on the recommendation of a doctor.

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