Treatment and Prevention

How to use the drug Gliclazide Canon?

Gliclazide canon is a drug with a hypoglycemic effect. With it, you can normalize glucose levels, hematological parameters and rheological functions of the blood. In addition, the drug has a positive effect on blood circulation and hemostasis, is used to prevent microthrombosis and inflammation in the walls of microvessels.

International non-proprietary name

INN medication: Gliclazide.

Gliclazide canon is a drug with a hypoglycemic effect.

Ath

A10BB09.

Forms of release and composition

The drug is produced in the form of pills, which are characterized by a prolonged release. The manufacturer offers 2 dosages: 30 mg and 60 mg. The tablets have a round biconvex shape and white color. The composition of the drug include:

  • active ingredient (gliclazide);
  • additional ingredients: colloidal silicon dioxide, cellulose microcrystals, magnesium stearate (E572), hydroxypropylmethylcellulose, mannitol, vegetable oil of hydrogenated type.

The drug is produced in the form of pills, which are characterized by a prolonged release.

pharmachologic effect

The principle of action of the drug is based on the effect on specific receptors of beta cells of the pancreas. Due to cellular interactions, depolarization of cell membranes and closing of CATF channels is performed. This leads to the opening of calcium channels and the entry of calcium ions into beta cells.

As a result, there is a release and increased secretion of insulin, as well as its transportation into the circulatory system.

The effect of the drug continues until the reserves of insulin production have been exhausted. Therefore, with prolonged therapy with these tablets, insulin synthesis is reduced. But after discontinuation of the medication, the reaction of beta cells is normalized again. In the absence of a therapeutic response, it is better to consult a doctor immediately.

The principle of action of the drug is based on the effect on specific receptors of beta cells of the pancreas.

Pharmacokinetics

The drug is absorbed from the gastrointestinal tract. With the simultaneous consumption of food decreases the speed of its absorption.

The therapeutic effect is observed after 2-3 hours. The maximum concentration of the active ingredient in the blood plasma is observed after 6-9 hours. The duration of exposure is 1 day after oral administration. The drug is excreted through the digestive tract and kidneys.

Indications for use

Tablets are prescribed for the treatment of non-insulin dependent diabetes mellitus (type 2), if diet, normalization of weight and therapeutic exercises do not contribute to positive dynamics. In addition, the drug is used to prevent complications of obesity, type 2 diabetes and to treat the latent course of the disease.

Tablets are prescribed for the treatment of non-insulin dependent diabetes mellitus.

Contraindications

The use of the drug is contraindicated in such conditions:

  • insulin-dependent diabetes mellitus (type 1);
  • age under 18;
  • lactation and pregnancy;
  • severe renal and hepatic impairment;
  • coma;
  • diabetic ketoacidosis;
  • IF (hypersensitivity) to sulfonamides and sulfonylurea derivatives;
  • individual intolerance to the components of the drug.
In a comatose state, taking the drug is prohibited.
In severe renal and hepatic impairment, taking Gliclazide Canon is prohibited.
The drug is not prescribed during pregnancy and lactation.
Children under 18 years of age are prohibited from taking the drug.

Carefully

The drug can be used for moderate and mild disorders of the kidneys and liver. The drug is prescribed with caution in such pathologies and conditions:

  • unbalanced or inadequate nutrition;
  • endocrine diseases;
  • severe diseases of the cardiovascular system;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • alcoholism;
  • elderly patients (65 years and older).

How to take Gliclazide canon?

Oral medication is intended exclusively for adult patients. The average daily dose is from 30 to 120 mg. The exact dosage is determined by the specialist based on the clinical picture.

The daily dose is recommended to use for 1 time, after drinking a whole pill. To prevent undesirable reactions, it is better to take the drug 30-40 minutes before a meal.

To prevent undesirable reactions, it is better to take the drug 30-40 minutes before a meal.

Treatment and prevention of diabetes

The initial dose of the drug in the treatment of insulin-independent diabetes and the use of sulfonylurea should not exceed 75-80 g. For prophylactic purposes, the drug is used at 30-60 mg / day. In this case, the doctor should carefully monitor the sugar level of the patient 2 hours after meals and on an empty stomach. If the dose is found to be ineffective, then it is increased in a few days.

Side effects

The drug has a good susceptibility of the body. However, with prolonged use of the drug in patients may experience adverse reactions.

For prophylactic purposes, the drug is used at 30-60 mg / day.

Gastrointestinal tract

  • diarrhea or constipation;
  • urge to vomit;
  • nausea;
  • pain and discomfort in the abdomen.

Hematopoiesis

  • anemia (reversible);
  • leukopenia;
  • agranulocytosis;
  • thrombocytopenia (in rare cases).

On the part of the skin

  • pruritus;
  • rash;
  • pale skin;
  • swelling of the face and limbs.
The drug can cause nausea, vomiting.
During treatment with Gliclazide Canon, diarrhea may occur.
Gliclazide Canon can cause abdominal pain.
Gliclazide Canon can cause itchy skin, rash.
During the course of drug treatment, an increase in blood pressure is possible.
Hepatitis may occur during treatment.
Increased intraocular pressure - a side effect of the drug.

Since the cardiovascular system

  • rapid heart rate (including tachycardia);
  • increase in blood pressure;
  • tremor.

Liver and biliary tract

  • hepatitis;
  • cholestatic jaundice.

By the organs of vision

  • loss of clarity of perception;
  • increased intraocular pressure.

special instructions

The drug is used in combination with a low-carb diet.

When taking it, the patient must control the concentration of glucose in the blood.

When taking the drug, the patient must ensure that the concentration of glucose in the blood is controlled.

In diabetes mellitus in the phase of decompensation or after surgery, consider the possibility of using insulin preparations.

Compatibility with alcohol

It is forbidden to drink alcohol in the treatment of the drug.

Influence on ability to operate mechanisms

Because of the risk of hypoglycemia in patients who take these pills, you should temporarily abandon the potentially dangerous activities and driving a car.

Use during pregnancy and lactation

Instructions for use of the drug prohibits it to take women in position and during breastfeeding.

Because of the risk of hypoglycemia in patients who take these pills, you should temporarily abandon the potentially dangerous activities and driving a car.

Purpose of Gliclazide canon for children

The drug is prohibited for use by young children.

Use in old age

Elderly patients are allowed to use the medication in the minimum dosage and under the close supervision of a physician.

Use in violation of kidney function

It is forbidden to use these pills with a hypoglycemic effect in marked renal pathologies. The dose is selected individually depending on the condition of patients with impaired renal function.

Use in violation of the liver

It is highly undesirable to use the medicine for acute and chronic liver diseases.

It is highly undesirable to use the medicine for acute and chronic liver diseases.

Overdose

Excess dosage of the drug may cause hypoglycemia. Moderate symptoms (without neurological signs and loss of consciousness) are normalized by the use of carbohydrates and adjustment of the diet and dose of medication.

In severe cases there is a risk of severe hypoglycemic reactions, which are accompanied by convulsions, coma and other neurological disorders. The victim in this case requires urgent hospitalization.

Dialysis procedures are ineffective because of the ligament of the active ingredient of the plasma protein tablets.

Interaction with other drugs

With the simultaneous use of the drug with other medicines can be faced with both positive and negative reactions. If negative symptoms occur, consult a doctor.

Contraindications

It is forbidden to use simultaneously with miconazole, as it increases the hypoglycemic effect of the drug. In addition, you can not prescribe phenylbutazone at the same time as this medicine.

Phenylbutazone should not be administered at the same time as Gliclazide Canon.

Combinations not recommended

It is undesirable to use ethanol-containing drugs and products based on chlorpromazine simultaneously with the preparation in question.

Phenylbutazone, Danazol and alcohol increase the hypoglycemic effects of the drug. In this case, it is better to choose a different anti-inflammatory drug.

Combinations that require caution

The combination of the drug with Acarbose, beta-blockers, biguanides, Insulin, Enalapril, Captopril and some anti-inflammatory nonsteroidal drugs and medicines containing chlorpromazine, requires special care, because in this situation there is a risk of hypoglycemia.

Glycazide MB is an analogue of the drug.
Gliclazide Canon has an analogue called Diabeton.
Oziklin - analogue of the drug Oxide Canon.

Analogs

In case of contraindications or the absence of a drug on sale, you can buy one of its synonyms:

  • Glycazide MB;
  • Diabeton;
  • Oziklid and others

Pharmacy vacation terms

Prescription drug.

Can I buy without a prescription?

Without a medical prescription, it is impossible to obtain medicine.

Without a medical prescription, it is impossible to obtain medicine.

Price Gliclazide canon

The cost of the drug in pharmacies in Russia ranges from 110-150 rubles per pack of 60 tablets.

Drug storage conditions

The drug is stored in a dark, dry and inaccessible to animals and children place. Temperature - no higher than + 25 ° C.

Shelf life

Not more than 2 years after production.

Manufacturer

Russian pharmaceutical company "Kanonfarma production".

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Gliclazide canon reviews

On specialized Internet resources about the drug generally respond positively. Negative reviews are related to non-compliance with medical recommendations.

Doctors

Sergey Shabarov (therapist), 45 years old, Volgodonsk.

A good drug, if used wisely. The dosage is selected very simply - 1 time per day (on average). Sugar level regulates effectively. In addition, the drug has a beneficial effect on the function of blood circulation and reduces the risk of complications of diabetes.

Anna Svetlova (therapist), 50 years old, Moscow.

Patients are satisfied when I prescribe these pills. I didn’t see any special side effects. One of the benefits of the drug is an affordable price. And its effectiveness is also on top!

Diabeton saccharifiers
Diabetes, Metformin, Diabetes Vision | Dr. Myasnikov

Diabetics

Arkady Smirnov, 46 years old, Voronezh.

If it were not for these pills, then my hands would have dropped long ago. I have long been ill with diabetes of the second type. This medicine regulates blood sugar well. Of the side effects, I only encountered nausea, but she went through herself after a couple of days.

Inga Klimova, 42, Lipetsk.

My mom has insulin-dependent diabetes. The doctor prescribed these pills for her. Now she became fun and felt the taste of life again.

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