Treatment and Prevention

How to use the drug Ofloxin?

The use of Ofloxin is necessary for a number of infectious-inflammatory diseases affecting various systems of the body. The drug has a wide spectrum of action, but has contraindications and causes side effects, so you should consult with your doctor before starting a course of therapy.

International non-proprietary name

Ofloxacin.

The use of Ofloxin is necessary for a number of infectious-inflammatory diseases affecting various systems of the body.

ATH

J01MA01. The drug belongs to the antimicrobial agents of systemic action, quinolone derivatives.

Forms of release and composition

There are 2 forms of Ofloxin on the pharmaceutical market: tablets and injection. In the first case, the drug is available in 2 dosages. An antibiotic unit contains 200 mg or 400 mg of the main active ingredient of ofloxacin.

Tablets of white color, film-coated, have a biconvex round shape, on the one hand divided by a risk, on the other an engraving with indication of dosage is applied. In this dosage form, the drug is presented in blister packs placed in cardboard packs.

The injection solution is a clear liquid with a yellowish-green shade. The drug is sold in glass bottles of 100 ml, each of which contains 200 mg of ofloxacin.

Tablets of white color, film-coated, have a biconvex round shape, on the one hand divided by a risk, on the other an engraving with indication of dosage is applied.

pharmachologic effect

The antibacterial agent belongs to the fluoroquinolone series and has a wide spectrum of action against gram-positive and gram-negative aerobic bacteria. Ofloxin activity is manifested against microorganisms such as:

  • Escherichia coli;
  • Salmonella;
  • Shigella;
  • Proteus;
  • Morganella morganii;
  • Klebsiella;
  • Enterobacter;
  • Citrobacter;
  • Haemophilus influenzae;
  • Neisseria gonorrhoeae;
  • Neisseria meningitidis;
  • Mycoplasma spp .;
  • Chlamydia spp .;
  • Staphylococcus;
  • Streptococcus.

Antibacterial effect does not apply to anaerobic bacteria. The active components of Ofloxacin penetrate into the focus of inflammation, block the synthesis of DNA gyrase, which is necessary for the normal functioning of the cells of the infectious agent. The growth, development and reproduction of bacteria stops.

The active components of Ofloxin penetrate into the focus of inflammation, block the synthesis of DNA gyrase.

Pharmacokinetics

The drug is rapidly absorbed and with the blood gets into various organs and tissues. The maximum concentration of the active substance is observed 60 minutes after administration. The antibiotic is distributed in the lungs, upper respiratory tract, urinary system, kidney and genital tissues, gall bladder, skin and bones. A high level of the active components of Ofloxin is observed in biological body fluids.

25% of the compounds that make up the antibiotic and perform therapeutic functions are associated with plasma proteins. The drug is 80% excreted in the urine in unchanged form. This happens a day after admission. Part of the medication is removed through the intestines. The half-life of the antibacterial agent is 6 hours. In people with low creatinine clearance, this interval is increased to 13.5 hours.

The drug is rapidly absorbed and with the blood gets into various organs and tissues.

Indications for use

The drug has proven effective in combating a number of infectious and inflammatory diseases caused by pathogenic microflora sensitive to Ofloxin. Indications for antibiotic use are:

  • severe bacterial lesions of the upper respiratory tract and lungs (acute and chronic bronchitis, pneumonia);
  • inflammatory processes in the upper respiratory tract (sinusitis, otitis media, sinusitis, pharyngitis, laryngitis);
  • infections of the gastrointestinal tract and biliary tract (except for bacterial enteritis);
  • damage to the skin, joints and bones;
  • diseases of the kidneys and urinary system (pyelonephritis, cystitis, urethritis);
  • inflammation of the prostate gland;
  • infections of the reproductive system (orchitis, colpitis, gonorrhea, chlamydia);
  • meningitis;
  • bacterial eye damage;
  • prevention of inflammation during surgical interventions;
  • various infections in people with immunodeficiency;
  • complex therapy of tuberculosis.

An antibiotic is prescribed by a doctor after examining the patient and determining the sensitivity of infectious agents to the drug.

The indication for use is chronic bronchitis.
This tool improves the condition of the affected joints.
The drug is used for the treatment of tuberculosis.

Contraindications

Pregnancy and breastfeeding are contraindicated. The drug is prohibited in case of individual intolerance to substances included in the composition, as well as in case of hypersensitivity to fluoroquinolones.

Do not use the drug in patients with deficiency of glucose-6-phosphate dehydrogenase. The drug is dangerous for those who suffered a stroke or has a history of CNS pathologies that reduce seizure threshold. Epilepsy is included in the list of contraindications. The antibiotic is not prescribed to children under 18 years of age.

Carefully

With organic lesions of the central nervous system and severe pathologies of the kidneys, it is better to give preference to another drug. The drug is prescribed with caution to people suffering from atherosclerosis of the cerebral vessels and other diseases associated with improper circulation.

In case of severe pathologies of the kidneys, it is better to give preference to another drug.

How to take Ofloxin

The dosage, regimen and duration of treatment are determined by the doctor based on the results of the analysis of the patient, his age and information about the accompanying pathologies. Tablets should be swallowed without chewing, drinking plenty of water. The solution for infusion is administered by intravenous drip.

For uncomplicated urinary tract infections, you should take 100 mg of ofloxacin 1-2 times a day. With pyelonephritis and inflammatory processes in the genitals, 100-200 mg are prescribed at regular intervals twice a day.

Bacterial lesion of the respiratory system, as well as infections affecting the ear, nose and throat, pathologies of soft tissues and the upper layers of the epidermis, bones and joints are treated with Ofloxin, using 200 mg 2 times a day. In case of severe disease, 400 mg of antibiotic is allowed twice a day.

With the defeat of the abdominal cavity and septic infections of the patient are treated according to the same scheme.
To prevent the development of infection in individuals with immunodeficiency spend infusion. To do this, you need 200 mg of ofloxacin mixed with 5% glucose solution. The duration of intravenous infusion is 30 minutes.

If the patient has a history of chronic kidney or liver disease, the instruction suggests reducing the volume of the antibiotic.

With diabetes

In diabetes, constant monitoring of blood glucose is necessary, since the combination of Ofloxin with drugs that regulate sugar content may cause hypoglycemia.

In case of missing a dose

If the patient did not take the antibiotic at the appropriate time, you should take a pill immediately when the medication omission was detected.

If the patient did not take the antibiotic at the appropriate time, you should take a pill immediately when the medication omission was detected.

Side effects

During treatment with fluoroquinolone, various negative reactions occur.

Gastrointestinal tract

Patients with antibiotic therapy may experience nausea, vomiting, diarrhea, or constipation. Painful abdominal cramps are not excluded. Some patients complain of flatulence, heartburn and dry mouth. In rare cases, bleeding occurs in the organs of the digestive tract, an increase in liver transaminase activity occurs, hepatitis and cholestatic jaundice, pseudomembranous enterocolitis develops.

Hematopoiesis

The action of the antibiotic provokes changes in the blood system, causing anemia, agranulocytosis, thrombocytopenia. Bleeding is possible. Rarely there is a negative impact on the process of blood formation in the bone marrow, an increase in prothrombin time occurs.

central nervous system

In some patients, severe reactions from the central nervous system are not excluded. People complain of dizziness and migraines, a violation of taste and smell, feel confused, feel heightened anxiety. Depressions, thoughts of suicide, phobias, paranoia are not excluded. In severe cases, seizures, hallucinations, paresthesia, impaired speech and coordination are possible.

As side effects are not excluded problems with the central nervous system.

From the musculoskeletal system

Taking fluoroquinolone antibiotics can cause exacerbation of myasthenia, arthralgia, and tendinitis. There is weakness in the muscles and the development of myalgia.

On the part of the respiratory system

Negative reactions manifest in the form of cough. Some patients have nasal discharge. In rare cases, bronchospasm and respiratory arrest are possible.

On the part of the skin

The development of photosensitization is not excluded. The antibiotic can cause increased pigmentation and provoke a rash on the skin.

From the genitourinary system

The drug causes dysuria and hematuria, nephritis, kidney stones, delays, or increased urination. Not exclude pain and rash in the urogenital area, vaginitis, candidiasis.

Since the cardiovascular system

When taking the drug can develop tachycardia, there is a sharp increase or decrease in blood pressure. In rare cases, pulmonary edema and cardiac arrest occur.

Problems with the cardiovascular system may develop when taking a medicine ...

On the part of the endocrine system

The drug provokes metabolic disorders. Patients celebrate thirst, weight loss. In diabetics, a sharp increase or decrease in the level of sugar in the blood is possible (in the presence of receiving the appropriate drugs). An increase in cholesterol, TG and potassium can be detected in serum.

Allergies

A common allergic reaction to an antibiotic is urticaria, pruritus and rash. Conjunctivitis, various types of erythema, angioedema, and anaphylactic shock are less common.

Influence on ability to operate mechanisms

The drug has a negative impact on the management of the car and other complex technical means, because it slows down psychomotor reactions and causes undesirable manifestations on the part of the central nervous system.

The drug has a negative impact on the management of the car and other complex technical means.

special instructions

There are conditions under which the drug is prohibited or severely limited.

Use during pregnancy and lactation

The active ingredients penetrate the placental barrier and are excreted in breast milk. Active ingredients cause malformations in children. Therefore, during pregnancy and breastfeeding to use the antibiotic is impossible. During lactation, if necessary, a course of therapy for the mother of the child should be transferred to artificial nutrition.

Purpose Ofloksin children

The drug is contraindicated in children under 18 years.

Use in old age

During the treatment of patients of mature age, it is necessary to constantly monitor vital signs. In most cases, the recommended adjustment of the dosing regimen, due to the risk of damage to the liver, kidneys and tendons in the elderly.

During the treatment of patients of mature age, it is necessary to constantly monitor vital signs.

Use in violation of kidney function

With low creatinine clearance, the daily volume of the antibiotic is reduced. Fluoroquinolone treatment for renal pathologies is controlled by specialists.

Use in violation of the liver

In chronic liver diseases, the medicine is prescribed with caution.

Overdose

If the recommended amount of the drug is exceeded, vomiting, dizziness, incoordination, confusion and disorientation are observed. There is no specific antidote. When ingestion of a large amount of antibiotic make gastric lavage. Then carry out symptomatic therapy.

Interaction with other drugs

The antibiotic increases theophylline concentration in the blood. Antacids and drugs containing magnesium, calcium, potassium and iron, reduce the absorbability of Ofloxin, therefore, should take these types of medications after 2 hours.

Non-steroidal anti-inflammatory drugs provoke seizures in the case of simultaneous use with fluoroquinolones. Glucocorticosteroids increase the risk of tendon rupture. Antibacterial drug with caution used in conjunction with hypoglycemic drugs. This combination can cause a sharp decrease in blood glucose levels.

Methotrexate and loop diuretics increase the toxicity of ofloxacin. When taken together with indirect anticoagulants, there is a risk of bleeding.

Compatibility with alcohol

Alcohol should not be taken during the course of antibiotic therapy. Alcohol increases the severity of side effects and reduces the effectiveness of the drug.

Analogs

Structural analogues of the drug on the main component are such drugs as Ofloxacin, Ofloks, Glaufloks, Taritsir, Unifloks. Substitutes of the antibiotic can be drugs from the group of fluoroquinolones: Nolitsin, Norfloxacin, Levofloxacin, Glevo.

Quickly about medications. Levofloxacin
Quickly about medications. Norfloxacin

Conditions of release Ofloksina from the pharmacy

Tablets and solution for infusions are distributed through pharmacies.

Can I buy without a prescription

An antibiotic is sold upon presentation of a prescription form certified by a doctor.

Price Ofloxin

The cost of the drug depends on the dosage and volume. Price ranges from 160 to 280 rubles.

Drug storage conditions

The drug should be stored out of reach of children at room temperature. Exposure to light and moisture should be limited.

Shelf life

The medicine must be used within 3 years from the date of production.

Ofloxin manufacturer

The drug is available in the Czech Republic by Zentiva A.C.

The medicine must be used within 3 years from the date of production.

Oploxine Reviews

Antibacterial agent received various reviews.

Doctors

Igor Vetrov, urologist, Minsk

Ofloxin is a powerful antibiotic, it is better to prescribe it only in severe cases. In case of mild to moderate infections, less toxic drugs can be used.

Irina Rozanova, otolaryngologist, Volgograd

The drug is effective, but requires careful study of the history and the correct choice of dosage.

Of patients

Angelina, 27 years old, Michurinsk

After a cold, bronchitis began. Assigned to receive Ofloxin. The temperature dropped every other day. Cough stopped for about 3 days. But now I can not get rid of dysbiosis and thrush.

Anton, 34 years old, Yaroslavl

Droppers with this antibiotic saved from pneumonia. I was in the hospital for 10 days.The side effects are unpleasant, but it is possible to survive an upset stomach to get back on its feet.

Watch the video: Ofloxacin 200 mg. use of ofloxacin. side effect of ofloxacin. precautions. what is ofloxacin? (September 2019).