Many patients suffering from diabetes have heard of a drug like Milgamma. Very often, patients ask the doctor if they can take this drug for diabetes. The answer to this question is unequivocal - not only possible, but necessary.
Milgamma in diabetes is used when the first signs of the development of problems in the functioning of the cardiovascular system appear in the body. The development of diabetic neuropathy affects the functioning of virtually all organs and organ systems.
The development of diabetic neuropathy is a factor aggravating the development in the body of diabetic diabetic foot and gangrene. In the case of progression of diabetes, the peripheral nervous system is affected.
This complication of diabetes is accompanied by tingling, numbness of the feet and a burning sensation.
In the case of the development of diabetic neuropathy in diabetes mellitus, the sensory nerves are damaged, which is manifested in a decrease in the patient's tactile and temperature sensitivity in relation to the external environment.
With the progression of the disease, the restoration of sensitivity is not possible. Prolonged progression of complications leads to the appearance of a diabetic ulcer of the leg. This complication is characterized by the loss of pain sensitivity in the skin and the appearance of microtraumas on the surface of the integument of the lower limbs.
Reduced sensitivity of the skin in type 2 diabetes provokes the appearance of microtraumas on the surface of the feet, which over time turn into ulcers and foci of inflammation.
Additionally, with the progression of diabetic neuropathy in a patient with diabetes mellitus, the appearance and progression of osteoporosis is observed, which leads to an increase in the likelihood of microtraumas and fractures of thin bones.
The use of the drug helps to normalize the functions of organs and blood vessels, improves concentration, eliminates the deficiency of B vitamins in the patient's body.
Milgamma composition and general information about the preparation
Means Milgamma in its composition contains therapeutic dosages of vitamins belonging to group B.
Vitamin complexes containing vitamins of group B, are used in the treatment of pathologies of nervous tissues and diseases of the nervous system that have a different genesis.
With the development of these diseases, inflammatory and degenerative processes arise and progress, which reduce the conductivity of the nervous tissue.
The composition of the drug Milgamma includes the following active ingredients:
- thiamine hydrochloride (vitamin b1);
- pyridoxine hydrochloride (vitamin b6 );
- cyanocobalamin (vitamin b12);
- lidocaine hydrochloride.
In addition to the main active ingredients, the drug contains auxiliary compounds. To the auxiliary chemical compounds that make up the Milgamma are:
- benzyl alcohol;
- sodium polyphosphate;
- potassium hexacyanoferrate;
- sodium hydroxide;
- water for injections.
The drug is used in medical practice in the treatment of the musculoskeletal system and disorders of the nervous system triggered by the development of diabetes in the human body.
The use of vitamins of group B can improve blood circulation in the body and intensify the blood-forming processes.
Introduction to the body of B vitamins stabilizes the nervous system, and the use of a complex of vitamins in a large dosage leads to pain relief.
Pharmacological effect of drug components on humans
When entering thiamine (vitamin b1) it is transformed into cocarboxylase. Without this bioactive compound, carbohydrate metabolism reactions cannot be carried out in the normal mode. Disorders of carbohydrate metabolism provoke the occurrence of failures in the nervous system.
The lack of thiamine leads to the accumulation in the body of intermediate carbohydrate metabolism products. The accumulation of intermediate products provokes the emergence of a variety of pathologies in humans.
The tablet form of the compound contains instead of thiamine a chemical compound - benfotiamine. This component of the drug is also actively involved in the implementation of carbohydrate metabolism reactions.
Pyridoxine is a compound belonging to the vitamins of group B. This compound is actively involved in the implementation of reactions of amino acid metabolism.
The compound takes an active part in the synthesis of such active mediators as:
- adrenaline (more information about adrenaline with diabetes);
Vitamin B6 takes an active part in ensuring the normal course of the formation of hemoglobin in the body.
Vitamin B12 It has an effect on the body as an anti-anemic compound and provides a process for the synthesis of such substances as:
- nucleic acids;
Vitamin B12 actively involved in the implementation of metabolism at the cellular level. In addition, this compound in the body acts as an analgesic.
The removal of thiamine from the body through the kidneys with urine. This biologically active compound does not accumulate in the cells of body tissues.
Cyanocobalamin takes an active part in the formation of complexes with albumin after its penetration into the blood plasma. The substance is able to easily penetrate the hemato-placental barrier.
Instructions for use of the drug
When using Milgamma, the initial dosage should be 2 ml. Introduction is carried out deeply intramuscularly. The drug is administered once a day.
In the implementation of maintenance therapy, a dosage of 2 ml is used once every two days. Maintenance therapy involves the use of a tablet form of the drug. In the case of tablets, the daily dose of the drug is 1 tablet per day; the drug is taken once.
When the need arises for the rapid relief of an attack of acute pain, intramuscular administration of the drug is used or a tablet form of the drug is used. Tablets should be used one at a time, three times a day.
The duration of the application of Milgamma is one month.
The indications for therapeutic use of Milgamma are:
- providing a tonic effect;
- development of neuritis and neuralgia;
- progression of polyneuropathy of alcoholic or diabetic origin;
- herpes infection nature;
- development of paresis of the facial nerve;
- development of radiculitis in a sick person;
- development of myalgia.
When using a drug in a patient, the following side effects may occur:
These symptoms are characteristic for too fast parenteral administration of a medical agent into the patient’s body or when the recommended dosage is significantly exceeded.
Contraindications for use of the drug are the following:
- The use of the drug is not recommended for children and adolescents who are under 16 years of age.
- The emergence of hypersensitivity to vitamins of group B.
- Failures in the processes of conduction of the heart muscle.
- The presence of a patient with heart failure.
The drug is not recommended for use during pregnancy and lactation. This is due to the fact that research on the effect of the drug on the child has not been conducted.
Interactions and consequences of overdose
It is not recommended to use the drug at the same time as drugs based on sulphate solutions. This is due to the fact that thiamine in such a combination completely disintegrates.
When thiamine metabolites appear in the preparation, the disintegration and inactivation of all the vitamins contained in the complex preparation occurs.
Inactivation of the drug occurs in the case of simultaneous use of Milgamma simultaneously with the following compounds:
- mercury chloride;
- ammonium ferric citrate;
- tannic acid;
Thiamine activity decreases markedly with an increase in pH and with the use of preparations containing copper.
Pyridoxine significantly reduces the effectiveness of anti-parkinsonian drugs, for example, a drug such as Levodopa. The use of drugs of this group and Milgamma should be separated in time. The presence in the body of heavy metal salts leads to inactivation of cyanocobalamin, a compound of Milgamma.
When an overdose occurs, there is an increase in symptoms characteristic of side effects. In case of overdose and the appearance of the first characteristic symptoms, symptomatic therapy is carried out.
The use of the drug does not affect the reaction rate, for this reason the use of the drug is permitted in cases where the concentration of attention and high speed of psychomotor reactions are required from the person taking the drug.
When taking the drug is allowed to control the road transport.
Product reviews, analogues, cost and storage conditions
The tablet form of the drug and vials for injection should be stored in a darkened and out of reach of children. The temperature at the storage location should not exceed 15 degrees Celsius.
The release of the drug is carried out exclusively by prescription, regardless of the form of manufacture of the medicinal product.
The use of this drug helps to normalize the functioning of nerve cells and prevents damage to the tissues of the extremities, prevents the appearance of degenerative changes in them.
With all its high efficacy, the remedy, judging by the opinions of patients who used it, is low-aggressive and can be perfectly combined with most of the drugs used in the treatment of diabetes. By reducing the dose of the drug, the drug is allowed to take pregnant and lactating women without any fear for the child's life.
Milgam, judging by the reviews of doctors and patients, significantly improves the symptoms of diabetic neuropathy, because folk remedies against diabetic neuropathy may not always achieve the desired result in a certain period. Its use is justified both in conducting therapeutic treatment and in preventing the occurrence of complications in the progression of diabetes mellitus in humans.
The following drugs are the most popular drug analogues:
- Milgamma Compositum.
The cost of the drug and its analogues in the Russian Federation depends largely on the manufacturer and region of the country.
Milgamma in 2 ml ampoules for injection, in packs of 5 pieces, has a cost depending on the region of the country from 219 to 428 rubles.
The tablet form of the drug is sold in packs of 30 tablets and has a cost in the range from 300 to 557 rubles. A video in this article will continue the topic of the drug.