Insulin

Rosinsulin: reviews of insulin use, instruction

Rosinsulin C is administered subcutaneously 1-2 times a day, about half an hour before eating. Each time should change the place of introduction.

In some cases, the endocrinologist may prescribe an intramuscular drug to the patient.

  • in diabetes mellitus type 1 and 2;
  • in a stage of resistance to hypoglycemic oral drugs;
  • with combined treatment (partial resistance to hypoglycemic oral medications);
  • with mono- or combination therapy for surgical interventions;
  • with intercurrent diseases;
  • in diabetes in pregnant women, when diet therapy does not give the desired effect.

Methods of administration and dose

Suspension for subcutaneous injection. Contraindications are hypoglycemia, hypersensitivity.

Rosinsulin C is administered subcutaneously 1-2 times a day, about half an hour before eating. Each time should change the place of introduction. In some cases, the endocrinologist may prescribe an intramuscular drug to the patient.

Note! The introduction of insulin medium duration of intravenous injection is prohibited! In each case, the doctor individually selects the dose, which may depend on the characteristics of the disease and the sugar content in the blood and urine.

The usual dose is 8-24 IU, which is administered 1 time per day, for this you can use insulin syringes with a removable needle.
In children and adults with high sensitivity to hormone, the dose can be reduced to 8 IU per day and, conversely, to patients with reduced sensitivity - increased to 24 IU per day or more.

If the daily dose of the drug exceeds 0.6 IU / kg, it is administered 2 times a day in different places. If the drug is administered in an amount of 100 IU per day or more, the patient should be hospitalized in the hospital. The replacement of one insulin to another must be carried out under the scrutiny of physicians.

Pharmacokinetics

The drug belongs to the insulin of the average duration of action, which is directed:

  1. to reduce the level of glucose in the bloodstream;
  2. to increase the absorption of glucose by the tissues;
  3. on increased glycogenogenesis and lipogenesis;
  4. to reduce the rate of glucose secretion by the liver;
  5. on protein synthesis.

Adverse events

Allergic reactions:

  • angioedema;
  • dyspnea;
  • hives;
  • decrease in blood pressure;
  • fever.

Hypoglycemic symptoms:

  1. increased sweating;
  2. pallor of the skin;
  3. hunger;
  4. heartbeat;
  5. anxiety;
  6. perspiration;
  7. excitation;
  8. tremor;
  9. paresthesias in the area of ​​the mouth;
  10. drowsiness;
  11. depressed mood;
  12. unusual behavior;
  13. irritability;
  14. uncertainty of movement;
  15. fear;
  16. speech and vision impairment;
  17. insomnia;
  18. headache.

When skipping an injection, a low dose, in the face of an infection or fever, if a diet is not followed, diabetic acidosis and hyperglycemia can develop:

  • decreased appetite;
  • thirst;
  • drowsiness;
  • facial flushing;
  • disturbance of consciousness up to coma;
  • at the beginning of therapy, transient visual disturbances.

Special recommendations

Before you take the drug from the bottle should be sure of the transparency of the solution. If sediment or turbidity is noticed in the preparation, then it cannot be used.

The temperature of the injection solution should be at room temperature.

Important! If the patient has infectious diseases, disorders of the thyroid gland, hypopituitarism, Addison's disease, chronic renal failure, as well as for persons over 65, insulin dose adjustment is necessary.

Causes of hypoglycemia can be:

  1. Drug replacement.
  2. Overdose.
  3. Skipping meals.
  4. Diseases that reduce the need for the drug.
  5. Vomiting, diarrhea.
  6. Hypofunction of the adrenal cortex.
  7. Physical stress.
  8. Change the injection area.
  9. Interaction with other drugs.

When transferring a patient from animal insulin to human insulin, a decrease in the concentration of sugar in the bloodstream is possible.

Description of the action of the drug Rosinsulin P

Rosinsulin P refers to drugs of short hypoglycemic action. Combined with the outer membrane receptor, the solution forms an insulin-receptor complex. This complex:

  • increases the synthesis of cyclic adenosine monophosphate in liver and fat cells;
  • stimulates intracellular processes (pyruvate kinase, hexokinase, glycogen synthase and others).

The decrease in blood sugar concentration is due to:

  1. increased intracellular transport;
  2. stimulation of glycogenogenesis, lipogenesis;
  3. protein synthesis;
  4. enhance drug absorption by the tissues;
  5. reduction of glycogen breakdown (due to a decrease in glucose production by the liver).

After subcutaneous administration, the effect of the drug comes in 20-30 minutes. The maximum concentration in the blood is reached in 1-3 hours, and the continuation of the action depends on the place and method of administration, the dose and the individual characteristics of the patient.

Indications for use

Rosinsulin P is used in the following cases:

  1. Type 1 and 2 diabetes.
  2. Partial resistance to hypoglycemic oral medications.
  3. Combination therapy.
  4. Ketoacidotic and hyperosmolar coma.
  5. Diabetic ketoacidosis.
  6. Emerged during pregnancy, diabetes.

For intermittent use:

  • during childbirth, injuries, forthcoming surgeries;
  • before switching to injections with prolonged insulin preparations;
  • with metabolic disorders;
  • with infections with intense fever.

Contraindications and dozone

Contraindications are hypoglycemia, hypersensitivity.

The route of administration of the drug and the dose in each case is determined individually. The basis for determining the dose is the sugar content in the bloodstream before and after meals, the course of the disease and the degree of glucosuria.

Rosinsulin P is intended for subcutaneous, intravenous and intramuscular administration. Injections do 15-30 minutes before meals. Most often, the solution is injected subcutaneously.

in surgical operations, diabetic ketoacidosis and coma, Rosinsulin P is administered intravenously and intramuscularly, for this it is necessary to know how to prick insulin correctly and accurately.

With monotherapy, the number of injections per day is 3 times. If necessary, they can be increased up to 5-6 times. In order to avoid the development of lipodystrophy, hypertrophy of fatty tissue, atrophy, it is necessary to change the injection sites every time.

Allergic reactions:

  • angioedema;
  • dyspnea;
  • decrease in blood pressure;
  • hives;
  • fever.

Symptoms of hypoglycemia:

  1. increased sweating;
  2. tachycardia;
  3. excitation;
  4. drowsiness;
  5. pallor of the skin;
  6. hunger;
  7. sense of anxiety;
  8. perspiration;
  9. tremor;
  10. paresthesias in the area of ​​the mouth;
  11. speech and vision impairment;
  12. uncertainty of movement;
  13. depression;
  14. strange behavior;
  15. irritability;
  16. apathy;
  17. insomnia;
  18. headache.

On the background of an infection or fever, when a patient misses an injection, a low dose, if a patient does not follow the diet, diabetic acidosis and hyperglycemia can develop:

  • loss of appetite;
  • thirst;
  • drowsiness;
  • swelling of the face;
  • disturbance of consciousness up to coma;
  • at the beginning of therapy, transient visual disturbances.

Special recommendations

Before you take Rosinsulin C from a vial, you must make sure that the solution is clear. If sediment or turbidity is observed in insulin, it cannot be used. The temperature of the solution for injection should be at room temperature.

Note! If the patient has infectious diseases, disorders of the thymus gland, hypopituitarism, Addison's disease, chronic renal failure, as well as for persons over 65, insulin dose monitoring is required.

The consequence of hypoglycemia can be:

  1. Drug change.
  2. Excess dose.
  3. Skipping meals.
  4. Diseases that reduce the need for the drug.
  5. Nausea, diarrhea.
  6. Insufficient function of the adrenal cortex.
  7. Physical exercise.
  8. Change of injection area.
  9. Interaction with other medicines.

When transferring a patient from animal insulin to human insulin, a decrease in the level of sugar in the bloodstream is possible.

Watch the video: Insulin Pump Downloads - Mayo Clinic Patient Education (September 2019).