Treatment and Prevention

Drug Gentadueto: instructions for use

Gentadueto is one of the drugs that are used in the treatment of diabetes. It has a persistent hypoglycemic effect and allows you to maintain a normal level of glucose for a sufficiently long period of time.

International non-proprietary name

INN: Linagliptin + Metforma

Gentadueto is one of the drugs that are used in the treatment of diabetes.

ATH

A10BD11

Forms of release and composition

The drug is produced in the form of film-coated tablets. The main active substance: linagliptin 2.5 mg and metformin hydrochloride dosage of 500, 850 or 1000 mg. Additional components are presented: arginine, corn starch, copovidone, silica, magnesium stearate. The film shell is formed by titanium dioxide, yellow and red iron dyes, propylene glycol, hypromellose, and talc.

Tablets 2.5 + 500 mg: biconvex, oval-shaped, film-coated yellow. On the one hand there is an engraving of the manufacturer, and on the other hand the inscription "D2 / 500".

Tablets 2.5 + 850 mg are the same, only the color of the film coating is light orange, and for tablets 2.5 + 1000 mg the color of the shell is light pink.

pharmachologic effect

Linagliptin - an inhibitor of the enzyme DPP-4. It inactivates the incretins and the glucose-dependent insulinotropic polypeptide. Incretins are involved in maintaining normal blood glucose levels. The active ingredient binds to enzymes and increases the concentration of incretins. Glucose-dependent insulin secretion increases, and glucagon secretion decreases, which normalizes the glucose indicator.

Metformin - biguanide. It has a persistent hypoglycemic effect. Plasma concentration of glucose decreases. The production of insulin is not stimulated, and therefore hypoglycemia develops only in rare cases. Synthesis of glucose in the liver is reduced due to inhibition of glycogenesis and gluconeogenesis. Due to the increased insulin sensitivity of surface receptors, the best utilization of glucose by cells occurs.

Metformin stimulates the synthesis of glycogen inside the cells.

Metformin stimulates the synthesis of glycogen inside the cells. It has a good effect on lipid metabolism. Reduces the concentration of cholesterol and triglycerides in the blood. The use of linagliptin together with sulfonylurea derivatives and metformin reduces HbA1c (by 0.62% compared with placebo; the initial HbA1c was 8.14%).

Pharmacokinetics

Active substances are rapidly absorbed from the digestive tract. On organs distributed unevenly. Bioavailability and ability to bind to protein structures is quite low. Excretion occurs after renal filtration, mostly unchanged.

Indications for use

Direct indications for use of this medication are:

  • treatment of type 2 diabetes in patients with insufficient glycemic control using the maximum dose of metformin;
  • combination with other drugs and insulin in adults with diabetic pathology, if the use of metformin and these drugs does not provide sufficient glycemic control;
  • treatment of people who have previously taken metformin and linagliptin separately.

A direct indication for the use of this medication is the treatment of type 2 diabetes in patients with insufficient glycemic control using the maximum dose of metformin.

It is used as an addition to diet and exercise to improve glycemic control in individuals with type 2 pathology.

Contraindications

It is strictly forbidden to use the drug in such conditions:

  • type 1 diabetes;
  • hypersensitivity to individual components;
  • diabetic ketoacidosis;
  • lactic acidosis;
  • condition of diabetic coma;
  • severe renal failure;
  • diseases that provoke tissue hypoxia: decompensation of heart muscle insufficiency, difficulty breathing, recently suffered a heart attack;
  • liver failure;
  • alcohol intoxication.
It is strictly forbidden to use the drug in such conditions as diabetic coma.
It is strictly forbidden to use the drug in such conditions as severe renal failure.
It is strictly forbidden to use the drug in such conditions as alcohol intoxication.
It is strictly forbidden to use the drug in such conditions as lactic acidosis.
It is strictly forbidden to use the drug in such conditions as type 1 diabetes.
It is strictly forbidden to use the drug in such conditions as diseases that provoke tissue hypoxia.
It is strictly forbidden to use the drug in such conditions as diabetic ketoacidosis.

Carefully

Special care must be taken in patients over 80 years old.

How to take Gentadueto?

The medicine is intended for oral administration. In order to reduce the occurrence of undesirable side effects, tablets are recommended to be taken during meals.

Diabetes Treatment

The daily dose is 2.5 mg + 500 mg, 2.5 mg + 850 mg, or 2.5 mg + 1000 mg. Drink pills twice a day. The dose is selected taking into account the severity of the clinical symptoms of the disease and the individual susceptibility of the body of active substances. The maximum daily dosage should not be higher than 5 mg + 2000 mg.

Side effects Gentadueto

Most often when combined with metformin Linagliptin diarrhea occurs. When taking linagliptin with metformin in combination with sulfonylurea derivatives, hypoglycemia most often occurs. It develops when taking linagliptin, metformin with insulin.

Common symptoms of adverse symptoms:

  • nasopharyngitis;
  • bouts of coughing;
  • decreased appetite;
  • diarrhea;
  • nausea;
  • skin rash with itching;
  • increased blood lipase levels;
  • hypoglycemia;
  • constipation;
  • abnormal liver function;
  • lactic acidosis;
  • taste disturbance;
  • abdominal pain.
While taking the drug may appear a side effect in the form of nausea.
A side effect such as diarrhea may occur while taking the drug.
While taking the drug may appear a side effect in the form of increased levels of lipase in the blood.
While taking the drug may appear a side effect in the form of abdominal pain.
While taking the drug may appear a side effect in the form of a rash on the skin.
While taking the drug may appear a side effect in the form of loss of appetite.
While taking the drug may appear a side effect in the form of cough.

Influence on ability to operate mechanisms

Does not affect.

special instructions

According to the research, if you combine the medication with sulfonylurea derivatives, the hypoglycemic effect occurs faster than the placebo reaction. The drug itself almost never causes hypoglycemia. If used improperly, lactic acidosis may occur, posing a threat to human life.

Repeated metformin in the treatment of alcohol intoxication can lead to the development of lactic acidosis, especially with long fasting, malnutrition or existing liver failure.

Use in old age

The medicine is permissible for administration to people over 65 years old. But you need to constantly monitor the function of the kidneys, because at older age, there are high risks for the development of renal pathologies in which metformin is contraindicated.

Appointment to children

The drug is not used in pediatric practice.

Use during pregnancy and lactation

You can not take pills in the gestational period. To avoid the risks of intrauterine abnormalities of the fetus, you need to switch to standard insulin as soon as possible.

There is not enough research on how quickly the active ingredients pass into breast milk, but the risk to the newborn is present. Therefore, for the period of such drug therapy is better to refuse breastfeeding.

In chronic insufficiency, the drug is not allowed, because Hepatitis and hepatic dysfunctions are possible when taking medication from the hepatobiliary system.
You can not take pills in the gestational period.
There is not enough research on how quickly the active ingredients pass into breast milk, but the risk to the newborn is present.
The drug is not used in pediatric practice.

Use in violation of kidney function

With high creatinine clearance, the drug is contraindicated. This also applies to chronic renal failure with a chronic course.

Use in violation of the liver

In chronic insufficiency, the drug is not allowed, because Hepatitis and hepatic dysfunctions are possible when taking medication from the hepatobiliary system.

Overdose Gentadueto

There is no data on overdose. In clinical studies, an overdose of linagliptin was observed. With a single dose of a high dose of metformin, hypoglycemia was not observed, but there were cases of lactic acidosis. Lactic acidosis is a complex condition that requires mandatory hospitalization. Metformin is eliminated from the body through hemodialysis.

Interaction with other drugs

Repeated administration of the drug or its active components separately does not change the pharmacokinetics of the drug. You can use the drug in conjunction with Glibenclamide, Warfarin, Digoxin and some hormonal contraceptive medicines.

Contraindications

Do not use the drug in conjunction with Ritonavir, Rifampicin and some oral contraceptives.

Do not use the drug in conjunction with Ritonavir.

Combinations not recommended

It is not recommended to combine taking pills with thiazolidinediones and some sulfonylurea derivatives, since they contribute to a sharp decrease in glucose and provoke glycemia.

Combinations that require caution

Use with cationic active medications such as Zimetidine. In such situations, it is necessary to monitor the work of the renal tubular transport systems and carefully monitor the amount of glucose in the blood plasma.

Compatibility with alcohol

You can not combine the pill with alcohol, because the therapeutic effect decreases, and the effect of the drug on the nervous and digestive system increases.

You can not combine the pill with alcohol, because therapeutic effect decreases.

Analogs

This medical preparation has many analogues similar to it in one or several active substances and therapeutic effects:

  • Avandamet;
  • Amaryl;
  • Duglimax;
  • Velmettia;
  • Janumet;
  • Vokanamet;
  • Galvusmet;
  • Glibomet;
  • Glibofor;
  • Glucovance;
  • Duotrol;
  • Dianorm-M;
  • Dibizid-M;
  • Casano;
  • Comboglysis;
  • Sinjardi;
  • Tripride.
METFORMIN from diabetes and obesity.
The sugar-reducing drug Amaril

Pharmacy vacation terms

To purchase is required to present a medical prescription.

Can I buy without a prescription?

Excluded.

Price for generadueto

Price data is not available, because now the medication is being retested.

Drug storage conditions

It is necessary to find a dry and dark place, at a temperature not higher than + 25 ° C.

It is necessary to find a dry and dark place, at a temperature not higher than + 25 ° C.

Shelf life

Not more than 3 years from the date of issue indicated on the original packaging. Do not use after this period.

Manufacturer

Production company: Beringer Ingelheim Pharma GmbH & Co. KG, Germany.

Reviews on Gentadueto

Irina, 37 years old, Ivanovo

A good drug that helps keep sugar levels normal for up to 12 hours. It is a pity that now it can not be found in pharmacies, you have to pick up other drugs with the same effect.

Vladimir, 64 years old, Murmansk

I took this drug for several years, until it disappeared from the sale. Sugar stayed on it, there were no side effects, it was convenient to enter. Now I had to look for a substitute.

Yaroslava, 57 years old, Chelyabinsk

Used this drug in combination with insulin. Diarrhea was severe. I had to replace it with another medicine.

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