Idrinol and Mildronate are based on the action of Meldonium hydronate, which is a synthetic analogue of gamma-butyrobetaine. Those. These are medicines that are recommended for improving metabolism.
To choose an effective remedy, it is necessary to familiarize yourself not only with the composition of drugs, but also with their indications, contraindications and side effects. But only a doctor can prescribe a drug on the basis of a survey and the results of tests. Self-use drugs are not recommended.
The drug is characterized by a high level of bioavailability - 78-80%. At the same time, it is rapidly absorbed into the blood, and within an hour its concentration will be maximal. Mainly excreted by the kidneys.
Idrinol is rapidly absorbed into the blood, and within an hour its concentration will be maximal.
You need to be careful when using drugs that lower blood pressure, as well as diuretics and bronchodilators.
Forms of release - capsules or injection solution. As for the encapsulated species, the drug is made with a dosage of 250 mg. Manufacturer - Sotex FarmFirma CJSC, registered in Russia.
Characteristics of Mildronata
This is not a new drug. It was first developed in the 1970s. in Latvia. Initially used in veterinary medicine, and its possibilities in the field of treatment of atherosclerosis and CHF were discovered somewhat later. Today, the drug is still produced by the Latvian company JSC Grindeks.
The main forms of release are 10% injection solution and hard gelatin capsules. Inside is a white powder.
Comparison of Idrinol and Mildronata
Both drugs have almost identical composition. The main component is meldonium. Although, due to the Olympic scandal, it is perceived by many as doping, the variety of pharmacological effects of the substance is wide. Athletes can be prescribed to improve blood circulation, increase the body's tolerance to stress. The medicine gives the body energy and tones the central nervous system.
Both drugs improve heart activity.
Since the drugs are based on the same substance, they act in the same way - they improve cardiac activity and normalize blood circulation in case of disorders of brain circulation. The drugs are recommended for atherosclerosis, diabetes.
Use in the composition of the same active ingredient, and in equal dosage, led to the presence of not only the same indications for use, but also almost identical contraindications and side effects.
A common feature for drugs is the presence in the composition of Meldonium. The latter has a variety of pharmacological effects, which include:
- restoration of oxygen delivery and increasing its level of consumption by cells;
- cardioprotective action (positive effect on the heart muscle);
- increase the body's ability to physical and mental labor;
- activation of natural immunity;
- reduction of symptoms of physical and psycho-emotional stress;
- reducing the likelihood of post-infarction complications.
Meldonium is also used in the treatment of diabetes mellitus, but only as part of complex therapy. It has a positive effect on the metabolism of lipids and glucose, this was confirmed by studies conducted in the early 2000s. In addition, Meldonium drugs help to fight diabetic polyneuropathy.
When taking drugs improves memory, they have a beneficial effect on the cognitive abilities of a person.
In acute ischemic myocardial damage, meldonium slows down the process of tissue necrosis and speeds up rehabilitation processes. In chronic heart failure, myocardial function is improved. In addition, patients are better tolerated exercise, they have reduced the number of angina attacks.
Side effects will be almost the same. It:
- dyspepsia (nausea, vomiting, heartburn);
- heart rhythm disorders, including tachycardia;
- psychomotor agitation;
- allergic reactions (pruritus, flushing, urticaria, or other types of rash);
- blood pressure drops.
But both drugs are well tolerated. Studies have shown that in patients with chronic cerebrovascular insufficiency, other cardiovascular diseases, there were no cases of withdrawal of meldonium drugs due to the development of side effects.
The indications for use of Idrinol and Mildronate mostly coincide:
- the postoperative period - to accelerate the recovery process;
- coronary heart disease, including angina pectoris, preinfarction condition and immediate heart attack;
- retinopathy in diabetes or hypertension;
- chronic heart failure (CHF);
- physical strain, including professional athletes;
- strokes and cerebrovascular insufficiency caused by acute and chronic disorders of the blood circulation of the brain (the drugs are included in the scheme of complex therapy);
- alcohol withdrawal syndrome (also in the complex treatment);
Sometimes drugs are prescribed for acute circulatory disorders in the retinal vessels, the presence of their thrombosis and even hemorrhages.
Contraindications for Mildronata and Idrinola are almost completely identical. These include:
- increased intracranial pressure;
- hypersensitivity to meldonium and auxiliary components of the drug.
Full-scale studies that would prove the safety of using meldonium for pregnant women have not been conducted. Therefore, Mildronate and Idrinol are not recommended for them. The same applies to their use for children and adolescents under 18 years of age.
The course of treatment is prescribed by the doctor, taking into account the characteristics of the disease, the patient's age, his general condition, etc. Much depends on the form of drug administration. For example, in ophthalmology, injection of injection solution is used for acute impairment of blood circulation in the retina. The maximum duration of the course of treatment in this case is 10 days.
For abnormal liver function, both drugs are prescribed with caution, the final decision remains for the doctor.
What is the difference?
Clinical practice shows that there is no difference between Mildronate and Idrinol. They have almost the same scope of application and contraindications. As for side effects, they also mostly coincide. The difference is that Mildronate is rare, but can cause headaches and swelling.
There are studies showing that Mildronate is used not only to correct blood circulation disorders after a stroke, but also to treat the depressive conditions that accompany this disease. The drug affects not only movement disorders and cognitive impairment, but also the psycho-emotional sphere. Thus, it increases the effectiveness of the rehabilitation program. For Idrinol such studies have not been conducted.
What is cheaper?
The price of Mildronate is from 300 rubles per dose of 250 mg to 650 rubles per capsule of 500 mg. Idrinol is cheaper. For a package with capsules of 250 mg of active ingredient, the patient will pay about 200 rubles.
What is better Idrinol or Mildronat?
An unequivocal answer to the question of what is better, Idrinol or Mildronate, is impossible. Both drugs are studied, have almost the same efficiency, have the same scope of application and are well tolerated by patients.
These drugs have analogues. And they are produced in Russia, for example, Cardionate. But Idrinol and Mildronate are considered more effective. Given that Idrinol is cheaper, it is often prescribed.
Svetlana, 42, Ryazan: “They diagnosed type 2 diabetes. The doctor, among other drugs, prescribed Mildronat. He was well tolerated, there were no allergies to it. I can say that there are improvements in terms of vision.”
Vladislav, 57, Moscow: "He was hospitalized with pre-infarction condition, many drugs were prescribed, including Mildronat. Given that the worst scenario was avoided, the medication works well."
Zinaida, 65 years old, Tula. "Idrinol was prescribed for coronary heart disease. A good drug, without side effects, and there is an improvement in well-being."
Both drugs are studied, have almost the same efficiency, have the same scope of application and are well tolerated by patients.
Doctors reviews about Idrinol and Mildronate
Vladimir, cardiologist, Moscow: "With chronic heart failure, I prescribe Mildronat, it is effective, well tolerated. There are studies that have a positive effect on the psychological state, attention also improves."
Ekaterina, neurologist, Novosibirsk: "I prescribe Mildronat for disorders of cerebral circulation. But you can replace the remedy with Idrinol - it is cheaper."