To monitor the level of glycemia, it is important for patients with diabetes. But not always just measuring the level of blood glucose reflects objectively the course of the disease. Plasma glucose concentrations can be affected by both the time of the day when the measurement is being taken, and physical activity before the test, as well as a number of other factors. Therefore, to answer the question about the severity of glycemia in humans, type of diabetes, as well as the effectiveness of treatment of the disease, more informative blood parameters are used.
Glucose, entering the blood from the organs of the gastrointestinal tract, due to its chemical activity, binds to the protein molecules of the blood. If blood glucose levels are higher than normal blood glucose concentrations, then excess glucose binds to any protein molecules, not just standard protein carriers. Therefore, there is an increase in the level of glycated hemoglobin and fructosamine (glucose compound and albumin plasma protein), as well as cell membrane proteins, which in turn causes diabetic complications in the form of macro and microangiopathies.
In contrast to glycosylated hemoglobin, which is an important indicator of the duration and degree of glycemia, during the previous few months, fructosamine allows to determine the presence of the degree of glycemia in the previous 14-20 days. This allows for effective monitoring of glucose levels in patients with diabetes.
When the fructosamine test is prescribed and how the research is conducted
For the study, the human venous blood is taken, in the first half of the day on an empty stomach and analyzed in the laboratory with a special analyzer. Normal blood fructosamine levels range from 200 to 300 µmol / L and depend on the type of analyzer that examines biological material.
The determination of the concentration of fructosamine in human blood is carried out in order to:
- Diagnostic confirmation of the presence of diabetes.
- Determination of the effectiveness of diabetes treatment.
Elevated fructosamine levels not only indicate the presence of diabetes mellitus, but can also be observed in renal failure, as well as in hypothyroidism (reduced thyroid function). Therefore, this laboratory analysis should be administered exclusively by a doctor and in combination with other studies (blood glucose, c-peptide analysis, etc.).