Many people wonder how to take Metformin correctly in order to achieve the most positive therapeutic effect.
In order to give an answer to this question, you should study in detail the instructions for using the drug and get advice from an endocrinologist.
The drug is available in the form of tablets, which are of three types, depending on the dosage: 500, 850 and 1000 mg. The main component contained in the preparation is metformin. Auxiliary substances in the composition of the drug are magnesium stearate, crospovidone, povidone K90, talc, corn starch.
Metformin, or Metformin hydrochloride is a member of the biguanide class, which helps eliminate hyperglycemia, that is, increase blood glucose. This drug is taken mainly in the second type of diabetes. In general, the patient taking the medicine will be relieved of the symptoms of hypoglycemia, since the following processes will occur in the body:
- Increased absorption of glucose by peripheral tissues.
- Slow down the process of splitting fats and proteins.
- Rapid glucose synthesis in the digestive tract and its transformation into lactic acid.
- Inhibition of the release of glycogen from the liver.
- Elimination of insulin resistance.
- Stimulation of glucose accumulation in the liver.
- Excretion of cholesterol, which favorably affects the state of lipids.
Metformin has virtually no effect on the functioning of the pancreas, which produces insulin. The drug can not lead to hypoglycemia - a decrease in the concentration of glucose in the blood.
Instructions for use of medication
Before you use Metformin, you need to know under what pathologies it is used.
It is better to follow the recommendations of the doctor who prescribes this tool, given the characteristics of each patient.
Indications for prescribing medications are:
- diabetes mellitus of the first and second type;
- prediabetes (intermediate state);
- obesity with impaired insulin tolerance;
- cleropolikistoz ovaries;
- metabolic syndrome;
- In sports;
- prevention of aging.
Despite the considerable list of pathologies under which you can drink Metformin, it is most often taken for diabetes of the second type. In the first type of the disease, this drug is used extremely rarely, mainly as an adjunct to insulin therapy.
Many studies have shown that while taking the drug at the same time as insulin injections, the need for the hormone decreases by almost 25-50%. In addition, after long-term use of the drug, the compensation of carbohydrate metabolism improves. It is also used in the second type of diabetes, requiring insulin injections.
In the second type of the disease, Metformin is prescribed in almost every case. During monotherapy, dosages should be increased gradually. So, in the beginning it is allowed to use 1 tablet per day (500 or 850 mg). It is best to take medicine in the evening, but to avoid disruption of the gastrointestinal tract, tablets are recommended to be drunk when eating food twice a day - in the morning and in the evening.
Over time, the dose of the drug can be increased by consulting with a doctor before. The maximum dose per day should not exceed 2.5 mg, that is, the patient can take 2-3 tablets per day. After two weeks, carbohydrate metabolism begins to return to normal. After reaching normal blood sugar levels, dosage can be gradually reduced.
The combination of the drug Metformin and sulfonylurea can produce a short-term positive effect. But the human body very quickly gets used to this kind of drugs. Therefore, monotherapy with Metformin can have a lasting effect. However, in 66% of patients with diabetes, such a combination of drugs really normalized carbohydrate metabolism.
Metformin is stored at a temperature of not more than 25C away from the eyes of children. Shelf life of the drug is 3 years.
Contraindications and side effects
Before taking this tool you need to make sure that it can be taken by the patient. Like other drugs, Metformin has some contraindications such as:
- period of carrying a child;
- children up to 10 years;
- chronic alcoholism;
- pathologies of the kidneys, liver, heart, and respiratory system;
- diabetic coma or precoma;
- previous lactic acidosis or predisposition to it;
- low-calorie diet;
- previous injuries and serious surgical interventions.
It should be a little more stop on lactic acidosis - the accumulation of lactic acid. Some conditions can lead to the development or aggravation of lactic acidosis:
- abnormalities in the kidneys, as a result, the inability to remove the acid;
- ethanol intoxication due to chronic alcoholism;
- heart and respiratory failure;
- obstructive pulmonary disease;
- infectious diseases that dehydrate the body - vomiting, diarrhea, fever;
- diabetic ketoacidosis (carbohydrate metabolism);
- myocardial infarction.
An incorrectly taken drug (overdose) can cause a number of negative consequences for the patient, for example:
- indigestion - nausea, vomiting, flatulence, diarrhea, metallic taste, reduced or complete lack of appetite;
- allergic reactions - skin rash and itching;
- lactic coma is a rare, but at the same time, dangerous complication.
Mostly adverse reactions pass by themselves after two weeks of taking the drug. This is due to the fact that the drug prevents the absorption of glucose in the intestine. As a result, carbohydrates begin to ferment in it, causing flatulence, and then other signs of disruption of the gastrointestinal tract. Often the body gets used to the action of the drug, and if adverse reactions are not too hard to tolerate, then no symptomatic treatment should not be carried out.
Before starting the administration of Metformin, the patient should tell about all the pathologies suffered and present, since hiding such important information can harm the patient.
Use of the drug for obesity
Many diabetics with the second type of the disease are overweight or obese.
In such cases, the use of the drug Metformin may have a positive effect on reducing the patient's body weight. But in order not to harm your own body, a diabetic should adhere to such recommendations:
- The course of therapy should last no more than 22 days.
- Taking pills, the patient must lead an active lifestyle.
- Taking the medication is accompanied by heavy drinking.
- Therapy restricts the patient to food.
Every day, a diabetic patient must perform certain physical activities, be it running, walking, swimming, volleyball, football, and so on. From the diet will have to exclude bakery products, pastries, chocolate, jam, honey, sweet fruit, fatty and fried foods.
The doctor determines the dosage of the drug for the patient. Self-medication can not be engaged, because it can lead to serious consequences. It can also be used by people who are not overweight but prone to fullness.
Often the dosage of the drug for them is slightly lower.
Price and analogues of the drug
The drug can be purchased at any pharmacy in the city or ordered online on the Internet. Since Metformin is produced by various domestic and foreign pharmacological companies, the price may differ significantly.
For example, if the manufacturer of the drug are Russian companies, then its cost, depending on the dosage, can be from 112 to 305 rubles. If the manufacturer is Poland, then the cost of the drug on the territory of the Russian Federation ranges from 140 to 324 rubles. A drug of Hungarian origin is on the territory of the Russian Federation from 165 to 345 rubles, depending on the amount of active substance in the product.
The price of the medicine is acceptable for people with moderate and low incomes. Therefore, you can choose the drug based on the expected therapeutic effect and financial capabilities of the consumer. Therefore, you can not overpay for expensive medicine that will have the same effect as cheap.
Since the drug is produced in many countries, it can have many synonyms, for example, Gliformin, Metfohamma, Bagomet, Forminpliva and others. There are also several effective similar drugs that can be taken when Metformin for some reason is not suitable for treating a patient. These include:
- Glucophage is an effective drug in the treatment of type 2 diabetes and obesity. It has hypoglycemic properties. These studies have shown that taking this drug reduces the death rate from diabetes by 53%, myocardial infarction - by 35%, stroke - by 39%. The average price (500 mg) - 166 rubles.
- Siofor is another good drug for lowering blood sugar levels. Its peculiarity is that the medicine can be combined with sulfonylurea preparations, salicylates, insulin and some others. Comprehensive treatment will improve the expected results. The average cost (500 mg) is 253 rubles.
Many patients think which medicine is better to choose? In fact, most drugs contain the active substance - metformin, the difference is only in excipients, so they have almost the same effect in the treatment of diabetes.
Patient Reviews for Metformin
Reviews of the use of the drug Metformin in most cases positive.
Many patients with type 2 diabetes note a decrease in blood glucose concentration to normal levels and keeping them at the same level.
In addition, the advantages of this tool are:
- convenient form of tablets that you need to swallow and drink water;
- application occurs one-time or in the morning and evening days;
- fairly low price of medication.
Many consumers also noted weight loss while taking Metformin. But at the same time you need to adhere to several rules: play sports, diet, drink plenty of fluids, limit yourself to food intake. To do this, you need to eat unsweetened fruits and vegetables, easily digestible carbohydrates, foods rich in fiber.
Sometimes you can find negative reviews of patients about this drug. They are mainly associated with adverse reactions to the drug. As mentioned earlier, most of the negative effects go away on their own after two weeks of treatment, because the body must get used to the action of metformin.
Metformin is an excellent medication used to reduce sugar in diabetes of the first and second type. It is used as a supplement to insulin therapy, as well as the main sugar-reducing drug in the second type of pathology. Before using the product, it is necessary to have a mandatory consultation with a doctor who will take into account all contraindications and prescribe the correct dosage.
In addition, Metformin without a prescription is not for sale. In fact, there are few contraindications and adverse reactions in the remedy, and their manifestation is very rare. In general, reviews of the drug are positive. Therefore, this drug can be considered harmless and effective.
In any case, drug therapy should be accompanied by constant monitoring of sugar level with the help of a glucometer, physical exertion and exclusion from the diet of fatty and fried foods, pastries, sweets. Only by observing all these rules, the patient will be able to achieve a long-lasting effect of the drug and keep the blood glucose level in the range of normal values.
About the rules for using Metformin will tell the video in this article.